Streptomyces malaysiensis WHL7 controls banana Fusarium wilt via glycerol-3-phosphate-induced microbiome remodeling (microbiomejournal.biomedcentral.com)

• WHL7 induces G3P secretion from banana roots.
• G3P enriches Bacillus and Pseudomonas, reducing Foc TR4 by 73%.
• Biocontrol effectiveness depends on native soil microbiota.

"The marine-derived Streptomyces malaysiensis WHL7 exhibited antagonistic activity against Foc TR4 in vitro. In pot experiments using natural soil, WHL7 treatment reduced Fusarium wilt incidence from 55% to 15%; no protection was observed in sterilized soil, indicating reliance on native microbiota. Integrated metabolomic analysis revealed that WHL7 stimulates root secretion of glycerol-3-phosphate (G3P), which enriches beneficial Bacillus and Pseudomonas species in the rhizosphere. Exogenous G3P reduced Foc TR4 abundance by 73% and induced systemic acquired resistance. The study highlights G3P-mediated priming as a sustainable strategy against soil-borne diseases."