Loss of Salivary Agglutinin (DMBT1) Alters Salivary Microbiome and Accelerates Oral Squamous Cell Carcinoma Development in Mice (microbiomejournal.biomedcentral.com)

• DMBT1 deficiency led to higher OSCC prevalence and more aggressive invasion.
• Lachnospiraceae and Sphingomonas showed genotype-specific time-dependent abundance differences.
• Causal evidence linking DMBT1 loss to oral dysbiosis and accelerated cancer development.

"This study demonstrates that loss of DMBT1, an antimicrobial salivary protein, disrupts the salivary microbiome and accelerates oral cancer development in a mouse model. Using 16S rRNA sequencing and longitudinal modeling, researchers identified genotype-specific microbial changes, with taxa such as Lachnospiraceae and Sphingomonas showing differential abundance over time. DMBT1 knockout mice developed more aggressive tumors compared to wild-type controls."