Genetic analysis of 619,372 individuals identifies over 88,000 metabolic trait associations from Estonian and UK Biobanks (nature.com)

• Combined analysis of Estonian Biobank and UK Biobank (n=619,372)
• Over 88,000 genetic associations with metabolic traits
• Rare variant associations at 1/10,000 frequency detected
• More than 8,000 genomic regions implicated

"A study combining Estonian and UK Biobanks (619,372 participants) identified over 88,000 associations between more than 8,000 genomic regions and circulating metabolic traits. The large sample enabled detection of rare variant effects present in 1 in 10,000 individuals. Published in Nature by Tambets et al., the work represents a significant expansion of known genetic influences on metabolism."