Curcumin Mitigates Aflatoxin B1-Induced Liver Injury in Sheep Through Rumen Microbiota Modulation (microbiomejournal.biomedcentral.com)

• Curcumin improves rumen fermentation and tight junction proteins under AFB1 exposure.
• Curcumin attenuates hepatic pyroptosis via the TLR4-NF-κB-NLRP3 pathway.
• Metagenomic and metabolomic data are publicly accessible.

"A study published in Microbiome on April 20, 2026, shows that dietary curcumin (800 mg/kg DM) counteracts aflatoxin B1 (AFB1, 500 µg/kg DM) toxicity in sheep by stabilizing rumen microbiota, enhancing barrier integrity, and modulating hepatic pyroptosis and autophagy. Curcumin improved rumen fermentation, upregulated tight junction proteins (ZO-1, Occludin, Claudin-1), reduced LPS, and downregulated TLR4-NF-κB-NLRP3 signaling, attenuating liver damage. Metagenomic and metabolomic data are deposited at NCBI SRA (PRJNA1263030) and OMIX (OMIX010302)."