Multi-omics study shows Enterococcus faecalis JM263 reduces liver injury in goats on high-concentrate diet via gut-liver axis (microbiomejournal.biomedcentral.com)

• E. faecalis JM263 supplementation attenuated HCD-induced intestinal and hepatic injury in goats.
• The probiotic enhanced intestinal barrier function and increased Muribaculaceae and Acetatifactor.
• Integrated proteomics and metabolomics revealed regulation of arachidonic acid metabolism and Nrf2/Keap1 pathway.
• Growth performance and immune function improved in treated goats.

"This study from Southwest University of Science and Technology (China) used integrated proteomics, metabolomics, and 16S rRNA sequencing to investigate how Enterococcus faecalis JM263, a strain from yak gut, alleviates liver damage in goats fed a high-concentrate diet. Twenty-four Yudong black goats were given 0.1, 0.5, or 1.0 g/kg of the probiotic for 60 days. Supplementation reduced intestinal and hepatic injury, improved growth and immune function. The probiotic reinforced intestinal barrier, increased Muribaculaceae and Acetatifactor abundances, and reduced oxidative stress via Nrf2/Keap1 pathway and arachidonic acid metabolism regulation. Correlation analysis linked gut microbiota changes to hepatic phenotypes. Findings suggest E. faecalis JM263 as a potential probiotic for ruminant health."