Duodenal Limosilactobacillus Enhances Feed Efficiency Through Ornithine-Mediated Gut Microbiota and Nrf2 Signaling Pathway in Broilers (static-content.springer.com)

• Study shows duodenal Limosilactobacillus vaginalis improves feed efficiency in broilers through ornithine production.
• Ornithine enhances polyamine metabolism, activating Nrf2 signaling and improving nutrient absorption.
• The research integrates microbiome analysis, metabolomics (polyamines), and molecular biology to elucidate mechanisms.
• Findings suggest potential for probiotic-based feed additives in poultry.

"This study investigates how duodenal-resident Limosilactobacillus (L. vaginalis) improves feed efficiency in broiler chickens by increasing ornithine production, which optimizes gut microbiota, enhances digestive enzyme activity, and upregulates nutrient transporter expression via Nrf2 signaling. The research identifies polyamine metabolism and Nrf2 pathway as key mechanisms. The findings suggest potential probiotic applications for improving feed efficiency in poultry."