Designed keystone metabolites boost shrimp disease resistance by recruiting symbionts via lipoxin A4–AP-1 pathway (static-content.springer.com)

• Keystone metabolites were designed to recruit beneficial symbionts.
• Lipoxin A4–AP-1 pathway mediates the protective effect.
• Shrimp disease resistance is significantly enhanced.

"Researchers designed keystone metabolites that enhance shrimp disease resistance by recruiting beneficial symbionts. The mechanism involves the lipoxin A4–AP-1 signaling pathway, linking metabolomics with host–microbiome interactions. This synthetic biology approach shows promise for aquaculture disease management."