Keystone metabolites pyruvic acid and DL-glutamine protect shrimp from white feces syndrome by recruiting symbionts via LXA4-AP-1 axis (microbiomejournal.biomedcentral.com)

• Pyruvic acid and DL-glutamine (1:2) identified as keystone metabolites against WFS in shrimp
• Recruitment of three beneficial bacterial strains (R. lacuscaerulensis, B. subtilis, N. nitratireducens)
• Mechanism involves LXA4 elevation and AP-1 suppression

"A study in Microbiome identifies pyruvic acid and DL-glutamine (1:2) as keystone metabolites that enhance disease resistance in Pacific white shrimp (Litopenaeus vannamei) against white feces syndrome (WFS). Dietary supplementation recruited beneficial bacteria Ruegeria lacuscaerulensis, Bacillus subtilis, and Nioella nitratireducens, strengthened gut network stability, and boosted immunity. A synthetic microbial community (SynCom) of these three strains replicated the effect. Both treatments elevated lipoxin A4 (LXA4) levels and suppressed the pro-inflammatory transcription factor AP-1. The findings provide a novel biocontrol strategy for aquaculture."