Mass Spec Roundup: Transformer-Based Peptide Sequencing, PM2.5 Molecular Profiling, Sediment Imaging, Glycan Aging Clock, and Dog Breath Analysis (theanalyticalscientist.com)

• RNovA transformer-based method achieves state-of-the-art de novo peptide sequencing and PTM discovery without database.
• Po Valley PM2.5 non-target MS reveals distinct seasonal and site-specific organic chemistry missed by mass-based metrics.
• FT-ICR MSI of sediments shows alkenone signal recovery depends on lamination; aggregation improves SNR.
• Absolute MALDI-TOF IgG glycan profiling in mice builds abGlycoAge clock, partly reversed by caloric restriction.
• SPME-GC-MS validates sugar cane polyphenol spray reduces odor-associated volatiles and malodor bacteria in dogs.

"A roundup of mass spectrometry studies: a transformer-based method (RNovA) for de novo peptide sequencing with PTM discovery; year-long PM2.5 molecular profiling in Italy's Po Valley revealing site-specific seasonal chemistry; FT-ICR MSI of marine sediments testing climate signal recovery; an IgG glycan aging clock in mice using absolute MALDI-TOF measurements; and a study on sugar cane polyphenol oral spray reducing dog halitosis, validated by SPME-GC-MS volatile profiling."