ASMS 2026 conference highlights five bioanalytical LC-MS posters from pharma and academic labs (bioanalysis-zone.com)

• Novo Nordisk EPP method uses ammonia in organic solvent for siRNA extraction, avoiding specialized kits or SPE.
• AstraZeneca top-down LC-MS method applied to bispecifics, ADCs, and catabolized biotherapeutics for stability and biotransformation studies.
• BMS product ion filtering uses a common payload fragment ion (m/z 108.0444) to profile ADC metabolites in mouse liver.
• Hong Kong Polytechnic University PCR-LC-MS workflow detects doping transgenes in horses via uracil-specific cleavage and ion-pair LC-MS.
• Medicilon method quantifies cyclic tetrapeptides at picogram levels using SCIEX 6500+ triple quadrupole with pH-controlled charge state optimization.

"Bioanalysis Zone curated five poster summaries from the 74th ASMS conference (May 31–June 4, 2026, San Diego). Posters detail methods for oligonucleotide extraction via enhanced protein precipitation (Novo Nordisk), top-down LC-MS for biotherapeutics (AstraZeneca), product ion filtering for ADC metabolites (Bristol Myers Squibb), PCR-LC-MS for equine doping transgenes (Hong Kong Polytechnic University), and cyclic tetrapeptide quantification (Medicilon). The article provides technical advice from each presenter."