Multi-body site microbial interactions shape the human plasma metabolome (microbiomejournal.biomedcentral.com)

• Microbiomes from gut, oral, skin, and nasal sites jointly explain 30.13% of plasma metabolome variance.
• Oral and gut microbiomes show synergistic interactions, particularly for indole derivatives and carboxylic acids.
• The oral-gut axis is functionally enhanced in insulin resistance, linking microbial crosstalk to metabolic dysregulation.

"A multi-cohort study (n=435) reveals that microbiomes from four body sites collectively explain 30.13% of inter-individual plasma metabolome variation. Gut microbiome contributes most (18.44%), followed by oral (14.70%), skin (11.52%), and nasal (5.88%). Oral and gut microbiomes exhibit strong synergistic interactions, especially along the oral-gut axis, regulating indole derivatives and carboxylic acids. This axis is amplified in insulin resistance, with enhanced microbial crosstalk linked to metabolic dysregulation. Findings emphasize integrating spatially distributed microbial ecosystems to understand host metabolism."