Gut microbiota and circulating metabolite associations with inflammation in children: a cohort study using Metabolon untargeted metabolomics and 16S sequencing (bmjopengastro.bmj.com)

• 149 microbial taxa and 87 metabolites significantly linked to inflammation markers in children aged 5-7 years
• Microbial metabolites showed stronger proportional associations with inflammation than non-microbial metabolites for InfSc and PAI-1
• Study confirms utility of Metabolon's untargeted metabolomics platform for integrative gut microbiome-metabolomics studies

"A study of 321 children from the Gen3G birth cohort used Metabolon's untargeted plasma metabolomics and 16S rRNA sequencing to examine associations between gut microbiota, circulating metabolites, and inflammation markers (PAI-1, MCP-1, TNF-α). The researchers found 149 microbial taxa and 87 metabolites associated with at least one inflammation marker after adjustment. Microbial metabolites were proportionally more associated with the overall inflammation score and PAI-1 than non-microbial metabolites. The study highlights the gut microbiota-metabolite-inflammation axis in pediatric health and demonstrates the application of Metabolon's platform in multi-omics research."