Study identifies Pantoea ananatis as a regulator of adaptive thermogenesis and lipid metabolism in high-altitude macaques (microbiomejournal.biomedcentral.com)

• Pantoea ananatis, enriched in high-altitude macaques, activates brown adipose tissue (BAT) and reduces fat storage.
• Multi-omics and gavage experiments show increased propionic acid and glycerolipid metabolism from high-altitude gut microbiota.
• Ferulic acid, a metabolite of P. ananatis, contributes to white adipose tissue reduction.

"Research published in Microbiome demonstrates that the gut bacterium Pantoea ananatis, enriched in high-altitude macaques, activates brown adipose tissue (BAT) and reduces white adipose tissue storage. Multi-omics and gavage experiments in mice and macaques showed that high-altitude gut microbiota enhances small intestine nutrient absorption, increases propionic acid, and activates glycerolipid metabolism. Ferulic acid, a metabolite of P. ananatis, also contributed to fat reduction. The study suggests P. ananatis as a potential probiotic for obesity intervention."