Mass spectrometry method detects ubiquitin on non-protein biomolecules, including glycogen in mouse liver (nature.com)

• New mass spectrometry method detects ubiquitin on non-protein biomolecules.
• In mouse liver, glycogen ubiquitination increases during fasting.
• Ubiquitination may regulate glycogen breakdown; involves 1% of total liver ubiquitin.

"A new mass spectrometry method has detected ubiquitin tags on non-protein biomolecules. In mouse liver, the energy storage molecule glycogen shows increased ubiquitination during fasting, involving about 1% of total liver ubiquitin. The findings suggest that ubiquitination may regulate glycogen breakdown into glucose."