Metabolon's Global Discovery Panel Used in Largest Metabolomic Study of CAR T-Cell Therapy Neurotoxicity (metabolon.com)

• Study analyzed >3,800 samples from six CAR T-cell trials using Metabolon's untargeted Global Discovery Panel.
• Metabolic scores for tryptophan, arginine, and polyamine pathways outperformed IL-6 and TNFα in predicting neurotoxicity.
• CSF samples confirmed CNS metabolic disruption during neurological events, linking blood and brain metabolome changes.

"Metabolon's untargeted Global Discovery Panel was used by Kite researchers to analyze over 3,800 samples from six clinical trials of CAR T-cell therapies (axi-cel and brexu-cel). The study identified metabolic pathways—tryptophan breakdown, arginine metabolism, and polyamine dysregulation—that are strongly associated with severe neurological events (NEs). Metabolite-based risk scores outperformed traditional inflammatory markers like IL-6 and TNFα in predicting neurotoxicity. Findings were published in Blood."