Five single-cell and spatial multiomics innovations built on 10x Genomics platforms from 2025 (10xgenomics.com)

• VISTA-FISH enables live-cell imaging on Xenium slides with integrated CRISPR screening
• MALDI-MSI allows spatial metabolomics on the same tissue section as Xenium
• CRISPore-seq detects transcript isoforms by combining short- and long-read sequencing

"A 10x Genomics blog post highlights five customer-developed innovations using their single-cell and spatial platforms from 2025. These include VISTA-FISH (live-cell microscopy on Xenium slides), MALDI-MSI (spatial metabolomics combined with Xenium transcriptomics), REFLEX (TCR sequencing with Flex), CRISPore-seq (combined short- and long-read sequencing for CRISPR screens), and virtual cell initiatives. The methods expand multiomic capabilities and demonstrate applications in neuroscience, immunology, and oncology."