Perspective article reviews lipidomics advances and future directions across health, nutrition, and environment (nature.com)

• Reviews technological advances: LC-MS, ion mobility, MS imaging, structural lipidomics.
• Highlights clinical translation: CERT2 risk score licensed to Quest Diagnostics, X-ALD newborn screening.
• Identifies challenges: standardization, quantification, dark lipidome, reference materials.

"This Nature Communications Perspective synthesizes current lipidomics technology, including LC-MS, ion mobility, mass spectrometry imaging, and computational tools. It highlights clinical translation such as the ceramide-based CERT2 risk score licensed to Quest Diagnostics and newborn screening for X-linked adrenoleukodystrophy. The article also covers applications in toxicology, food science, and ecology, while emphasizing challenges in standardization, quantification, and data interoperability. Future directions point toward precision medicine and population health studies."