Lipidomics Perspective Article Outlines Roadmap for Basic Research to Societal Applications (nature.com)

• Advances in MS and chromatography enable high-resolution lipidome mapping across biological scales.
• Lipidomics is applied to biomarker discovery, drug development, nutrition, and environmental monitoring.
• Major hurdles include standardization of workflows, annotation accuracy, and limited reference materials.

"This Nature Communications perspective synthesizes the current state of lipidomics, highlighting advances in mass spectrometry, chromatography, and computational analysis that enable high-resolution mapping of lipid networks. It covers applications in biomarker discovery for cancer, metabolic, and neurodegenerative diseases; drug discovery; food and nutrition science; and environmental ecology. Major challenges include annotation accuracy, standardization of workflows, and limited availability of isotopically labeled standards. The article outlines future directions for translating lipidomic knowledge into societal and environmental benefits."