Spatial proteome map of human body and cancers from 2,856 DIA-MS samples (nature.com)

• 13,609 proteins quantified across 58 healthy adult tissue types, 22 fetal tissues, and 25 cancers using DIA-MS.
• Pan-cancer analysis identifies 8,940 differentially expressed proteins; 2,878 are tumor-specific.
• Resource enables drug target prioritization and repurposing, exemplified by Trodelvy and olaparib for endometrial cancer.

"Researchers at Westlake University and collaborators published in Nature a spatially resolved map of the human proteome, profiling 13,609 proteins across 2,856 samples from 58 tissue types, 251 subtypes, and 25 cancers using data-independent acquisition mass spectrometry. The dataset includes fetal, tumor, adjacent non-tumor, and healthy adult tissues. Analyses reveal proteome trajectories along development and oncogenesis, tissue-specific drug targets, and pan-cancer differentially expressed proteins. The resource is intended for organ-specific toxicity prediction, drug repurposing candidate identification, and therapeutic target prioritization."