1,700 new small proteins discovered in dark proteome (prinsesmaximacentrum.nl)

• 1,700 new micro-proteins (peptideins) discovered from non-canonical ORFs
• Validated using proteomics, ribosome profiling, CRISPR screening
• Added to public databases: GENCODE, UniProt, PeptideAtlas
• Potential role in cancer and other diseases

"International consortium identifies 1,700 previously unknown micro-proteins called peptideins, encoded by non-canonical open reading frames (ncORFs) in the human genome. The proteins were detected using advanced proteomics and ribosome profiling, and have been added to reference databases (GENCODE, UniProt, PeptideAtlas). Some are essential for cell survival; potential implications for disease including childhood cancer. The study was published in Nature and led by researchers from Princess Máxima Centrum (Netherlands), University of Michigan, and Institute for Systems Biology."