Human Microprotein Atlas platform annotates over 600,000 microproteins (nature.com)

• Integration of 617,462 microproteins from public databases
• Structure prediction with AlphaFold2 and functional annotation via DeepFRI
• ESM-2-based prediction of localization, essentiality, and bioactivity

"Researchers from Peking University introduced the Human Microprotein Atlas (HMPA) platform, integrating 617,462 human microproteins from sources like SmProt and sORFs.org. The platform provides sequence features, predicted 3D structures (AlphaFold2), variant effects, subcellular localization, essentiality, and bioactivity predictions using the ESM-2 protein language model. A web server enables interactive exploration. The study identified candidate microproteins for pancreatic cancer therapy."