Correlation of Sleep Metrics with Blood Biomarkers in Empirical Health Members (empirical.health)

• 79 out of 444 biomarker-sleep metric correlations statistically significant (p<0.05)
• Strongest single correlation: sleep quality with lymphocyte percentage (r=+0.272)
• Sleep duration negatively associated with HbA1c and estimated average glucose
• Deep sleep percentage associated with kidney function (eGFR) and liver enzyme (AST)

"An analysis of 7,033 paired observations links Apple Watch sleep data to 74 blood biomarkers. 79 correlations reached p<0.05, with strong signals in immune cell ratios and glucose metabolism. The study is observational and unadjusted."